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International Name : Xiaflex

Contains : Collagenase Clostridium Histolyticum

Manufacturer : Auxilium Pharmaceuticals, Inc.

Form : Vial /injection

Packing : Single dose Vial

Strength : 0.9 mg per vial

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This medicine is utilized to treat certain conditions (Dupuytren’s contracture, Peyronie’s sickness) that are caused by a specific protein (collagen) in your body.

Collagen is a tough and solid substance and is found in the bunches/strings(cords) of the hand in Dupuytren’s contracture or plaques in the penis in Peyronie’s disease. Collagenase is a substance (enzyme) that separates the collagen in these knots or bunches/cords/plaques.


Read the Medication Guide given by your doctor before every infusion or injection. If you have any inquiries, ask your specialist or drug specialist.

If you are utilizing this medicine to treat Dupuytren’s contracture, the drug is infused or injected into the tissue knot(string) of the influenced hand by a healthcare provider.

Your hand will be enclosed by delicate cloth after the infusion. Limit hand movement and keep the hand raised until sleep time.

Try not to attempt to rectify, twist, or move the infused finger until the point that your specialist reveals to you it is alright to do as such. Tell your specialist immediately If you begin to feel deadness, shivering, or sentiment of “pins and needles” in your hand during the method.

You should come back to your specialist’s office inside 1 to 3 days after the procedure. Your specialist will check your hand, attempt to fix the finger if necessary, and apply for support.

Wear the support each night at sleep time as long as coordinated by your specialist (for as long as 4 months). Do finger practices a few times each day precisely as coordinated. Try not to do any strenuous movement with the treated hand until the point that your specialist reveals to you it is alright to do as such. Tell your specialist if you experience difficulty twisting the finger after the swelling goes down or issues utilizing your hand.

If you are as yet helpless to fix your finger following a month, your specialist may give a recurrent infusion into a similar zone of the hand. Close to 3 infusions, every a month separated, should be given in a similar area.

In the event that you are utilizing this medicine to treat Peyro nie’s malady, the prescription is infused into the plaque in the penis by your healthcare provider. Every treatment cycle comprises of two infusions 1 to 3 days separated and a displaying (fixing) strategy 1 to 3 days after the second infusion. Try not to engage in sexual relations between the first and second infusions of a treatment cycle.

Additionally, don’t have any sexual movement for something like 2 weeks after the second infusion of a treatment cycle and simply after your specialist says that it is protected to do as such (for the most part after all the torment/swelling has left).

You may have upwards of 4 treatment cycles. Every treatment cycle is around about a month and a half separated. In the middle of cycles, follow to your specialist’s guidelines on rectifying and extending the penis. Tell your specialist in the event that you experience difficulty extending or rectifying your penis or if new pain occurs.

Side Effects :

  • Pain
  • Swelling
  • Bruising
  • Bleeding
  • Redness
  • Itching at or around the injection site may occur
  • Fever
  • Allergic reaction

This is not an exhaustive list of side effects and others may occur. Please contact your doctor immediately if any of these symptoms are found.




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