Onpattro 10mg / 5ml

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Onpattro 10mg / 5ml

International Name : Onpattro 10mg / 5ml

Contains : Patisiran

Manufacturer : Alnylam Pharmaceuticals

Form : Vial

Packing : 1 Vials

Strength : 10mg / 5ml

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Onpattro 10mg / 5ml


Onpattro (patisiran) is demonstrated for the treatment of stage 1 or stage 2 polyneuropathy in grown-up patients with genetic transthyretin amyloidosis (hATTR).

What is Onpattro (patisiran)?

Onpattro (patisiran) is shown for the treatment of stage 1 or stage 21 polyneuropathy2 in grown-up patients with genetic transthyretin amyloidosis (hATTR)1,2.

Polyneuropathies, or fringe neuropathies, result from harm to the fringe (nerves that go from the spinal rope to the arms, hands, legs, and feet). This degeneration of the neurons is dynamic and causes shortcoming, deadness and agony in the extremities4.

How does Onpattro (patisiran) work?

Transthyretin amyloidosis is an uncommon ailment portrayed by the nearness of a damaged blood protein called transthyretin (TTR)7. This imperfect protein breaks effectively, which results in the statement of a stringy substance (amyloid fibrils) inside the body7. The aggregation of amyloid fibrils makes harm body structures, similar to tissues and organs, and keeps their typical function7. Side effects and signs can vary contingent upon the area of the amyloid protein deposits5. At the point when the nerves are influenced the illness is called genetic transthyretin amyloidosis (hATTR)8.

Patisiran is the first of another class of focused RNA-based treatments meddling with the creation of freak transthyretin (TTR) protein3,6. Along these lines, it diminishes the development of amyloids and soothes the side effects of polyneuropathy related to hATTR amyloidosis6.

Where has Onpattro (patisiran) been affirmed?

Onpattro (patisiran) was affirmed for the treatment of stage 1 or stage 2 polyneuropathy in grown-up patients with innate transthyretin amyloidosis (hATTR)1,2 by:

Sustenance and Drug Administration (FDA), USA, October 6, 20181 European Medical Agency (EMA), European Union, August 27, 20182.

If it’s not too much trouble take note of that this medication may have additionally been affirmed in different areas than the ones we’ve recorded. In the event that you have an inquiry regarding its endorsement in a particular nation don’t hesitate to contact our help group.

How is Onpattro (patisiran) taken?

The prescribed Onpattro (patisiran) dose depends on body weight1,2:

For patients weighing under 100 kg, 0.3 mg/kg as an intravenous implantation once at regular intervals

For patients gauging in excess of 100 kg, 30 mg as an intravenous mixture once at regular intervals.

All patients ought to get premedication before Onpattro organization to diminish the danger of

implantation-related reactions1. The typical premedication ought to be given no less than an hour before the beginning of infusion1.

Complete data about Onpattro (patisiran) dose and organization can be found in the authority endorsing data recorded in our assets section1,2.

Note: Please counsel with your treating specialist for customized dosing.

Are there any known symptoms or antagonistic responses of Onpattro (patisiran)?

Regular unfriendly responses

The most widely recognized unfriendly responses recorded in the recommending data include1,2:

upper respiratory tract contaminations

implantation related responses, for example,

stomach torment

feeling debilitated

body hurts

a cerebral pain



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